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Wholesale China Suppliers Factory 99% Pure Beta Nicotinamide Mononucleotide NMN Powder CAS 1094-61-7
Description
Nicotinamide mononucleotide (NMN), a product of the NAMPT reaction and a key NAD+ intermediate, ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. NMN also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation. NMN is used for studying binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments.
β-Nicotinamide mononucleotide (β-NMN) is an intermediate in the nicotinamide phosphoribosyltransferase (NAMPT)-catalyzed biosynthesis of nicotinamide adenine dinucleotide (NAD+). NAMPT mediates the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to produce β-NMN. β-NMN adenyltransferase subsequently converts β-NMN to NAD+.
Application
β-Nicotinamide mononucleotide (NMN) is a product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation. It is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments.
Uses
β-Nicotinamide mononucleotide (NMN) is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments. NMN is a nucleotide derived from ribose and nicotinamide. Niacinamide (nicotinamide) is a derivative of vitamin B3, also known as niacin. As a biochemical precursor of NAD+, it may be useful in the prevention of pellagra.
Key Biosynthesis Mechanism
β-Nicotinamide mononucleotide is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to generate β-NMN, which is subsequently converted to NAD+ by β-NMN adenyltransferase. At 50-100 μM, β-NMN has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in a Nampt+/- mouse model of metabolic disease, demonstrating a role for Nampt in β cell function. Furthermore, at 500 mg/kg/day, it has been shown to ameliorate glucose intolerance in high-fat diet-induced type 2 diabetes mice by restoring NAD+ levels.
Benefits
As one of the primary precursors of NAD+ and intermediaries in NAD+ biosynthesis, NMN is as essential as NAD+ in the body’s proper functioning of cells. NAD helps cells regulate a number of essential functions that help keep your cells running smoothly, including: energy metabolism, DNA repair, gene expression, and cellular stress responses.
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Frequently Asked Questions
What is Nicotinamide Mononucleotide (NMN)?
Nicotinamide mononucleotide (NMN) is a nucleotide derived from ribose and nicotinamide (a derivative of vitamin B3). It is a key intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+) and plays a crucial role in maintaining cellular functions.
How does NMN benefit glucose tolerance and insulin sensitivity?
NMN ameliorates glucose intolerance by restoring NAD+ levels. Research shows that it enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through the activation of SIRT1.
What are the primary applications of NMN in research?
NMN is widely used in laboratory settings to study binding motifs within RNA aptamers and to research ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments.
What role does NMN play in the biosynthesis of NAD+?
NMN is an essential intermediate in the biosynthesis of NAD+. The enzyme Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to produce β-NMN, which is then converted to NAD+ by β-NMN adenyltransferase.
What are the key cellular functions regulated by NAD+?
NAD+ helps cells regulate several essential functions that keep cells running smoothly, including energy metabolism, DNA repair, gene expression, and cellular stress responses.