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Tetracaine Base Powder CAS 94-24-6 - Local Anesthetic from China Suppliers and Factory
What is Tetracaine?
Tetracaine is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount.
Function
99.9% Pure Tetracaine powder cas 94-24-6 is a benzoate ester with anesthetic properties. Upon administration, 99.9% Pure Tetracaine powder cas 94-24-6 reversibly binds voltage-gated sodium ion channels in neuronal cell membranes and inhibits sodium influx. This prevents the initiation and conduction of nerve impulses, and stabilizes neuronal membranes. This results in a loss of sensation, and thereby provides analgesia and anesthesia.
Application
Tetracaine, also known as amethocaine, is an ester local anesthetic used to numb the eyes, nose, or throat. It may also be applied to the skin before starting an intravenous to decrease pain from the procedure. Typically it is applied as a liquid to the area. Onset of effects when used in the eyes.
Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
Solubility Note:
HCl soluble in water, base insoluble in water. (Some Base dissolves in hot water!)
Local Anesthesia Strength Comparison (Some base effect is stronger than HCl):
Tetracaine
>
Lidocaine
>
Benzocaine
>
Procaine
Details
Frequently Asked Questions (FAQ)
Q: What is the synthesis process of Tetracaine?
Tetracaine is synthesized from 4-butylaminobenzoic acid. Its ethyl ester is formed through acid-catalyzed esterification, followed by base-catalyzed transesterification by boiling the ethyl ester with excess 2-dimethylaminoethanol.
Q: How does 99.9% Pure Tetracaine powder produce anesthetic effects?
It reversibly binds voltage-gated sodium ion channels in neuronal cell membranes. This action inhibits sodium influx, preventing the initiation and conduction of nerve impulses, stabilizing neuronal membranes, and resulting in a loss of sensation.
Q: What are the primary medical applications of Tetracaine?
Tetracaine is mainly used to numb the eyes, nose, or throat, and can be applied to the skin before intravenous procedures to reduce pain. It is also used topically in ophthalmology, as an antipruritic, and in spinal anesthesia.
Q: How is Tetracaine utilized in biomedical research?
In biomedical research, it is used as an allosteric blocker to alter the function of calcium release channels (ryanodine receptors) controlling intracellular calcium release. Low concentrations inhibit spontaneous release, while high concentrations block it completely.
Q: What is the difference in solubility between Tetracaine HCl and Tetracaine Base?
Tetracaine HCl is soluble in water, whereas Tetracaine Base is generally insoluble in water, though some base form can dissolve in hot water.
Q: How does Tetracaine's local anesthetic strength compare to other anesthetics?
Tetracaine exhibits strong anesthetic properties, with a strength profile ranking as: Tetracaine > Lidocaine > Benzocaine > Procaine. Additionally, the anesthetic effect of some base forms is stronger than the HCl form.