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Tetracaine Base Powder CAS 94-24-6 - Local Anesthetic from China Suppliers and Factory
What is Tetracaine?
Tetracaine is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount.
Function
99.9% Pure Tetracaine powder cas 94-24-6 is a benzoate ester with anesthetic properties. Upon administration, 99.9% Pure Tetracaine powder cas 94-24-6 reversibly binds voltage-gated sodium ion channels in neuronal cell membranes and inhibits sodium influx. This prevents the initiation and conduction of nerve impulses, and stabilizes neuronal membranes. This results in a loss of sensation, and thereby provides analgesia and anesthesia.
Application
Tetracaine, also known as amethocaine, is an esterlocal anesthetic used to numb the eyes, nose, or throat.It may also be applied to the skin before starting anintravenous to decrease pain from the procedure.Typically it is applied as a liquid to the area. Onset ofeffects when used in the eyes.
Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
Tips & Solubility Info
Solubility: HCl form is soluble in water, while the base form is insoluble in water. (Note: Some Base dissolves in hot water!)
Anesthesia Strength: The anesthesia effect of some base is stronger than HCl.
Anesthetic Strength Comparison:
Tetracaine >
Lidocaine >
Benzocaine >
Procaine
Details
Frequently Asked Questions (FAQ)
What is Tetracaine and how is it synthesized?
Tetracaine is synthesized from 4-butylaminobenzoic acid. The synthesis process involves forming an ethyl ester via an acid-catalyzed esterification reaction, followed by base-catalyzed transesterification achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol.
What is the primary function of Tetracaine powder?
Tetracaine is a benzoate ester with potent anesthetic properties. It works by reversibly binding to voltage-gated sodium ion channels in neuronal cell membranes. This action inhibits sodium influx, preventing the initiation and conduction of nerve impulses, which stabilizes neuronal membranes and leads to a temporary loss of sensation.
What are the typical medical applications of Tetracaine?
Tetracaine is widely used as a local anesthetic to numb the eyes, nose, or throat, and is applied topically to the skin before starting intravenous procedures to reduce pain. It is also utilized in ophthalmology, as an antipruritic (to relieve itching), and in spinal anesthesia.
How is Tetracaine used in biomedical research?
In biomedical research, tetracaine serves as an allosteric blocker to alter the function of calcium release channels (ryanodine receptors) that regulate intracellular calcium release. Low concentrations of tetracaine inhibit spontaneous calcium release events, whereas high concentrations block the release entirely.
What is the difference in solubility between Tetracaine HCl and Tetracaine Base?
Tetracaine HCl is soluble in water, whereas Tetracaine Base is insoluble in water. However, some forms of the base can dissolve in hot water. Additionally, the local anesthetic strength of the base form is generally stronger than that of the HCl form.
How does the anesthetic strength of Tetracaine compare to other local anesthetics?
Tetracaine is a highly potent local anesthetic. In terms of local anesthesia strength, it ranks highest in the following order: Tetracaine > Lidocaine > Benzocaine > Procaine.