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Pramoxine Hydrochloride Powder CAS 637-58-1 - Local Anesthetic Suppliers and Factory in China
Description
Pramoxine, also known as pramocaine, is different from other local anesthetic compounds in chemical structure. Active groups which are carboxylic acid derivatives like ester and amide are not present in this molecule. The drug molecule consists of ether functional groups that are much less active on a chemical level. The presence of the free radical morpholine in this compound is the cause of the reduction of the factor of toxicity and pharmacological activity. In pramoxine, toxicity is reduced but the local anesthetic affect is maintained.
Uses
Pramoxine Hydrochloride is used as a local anaesthetic and often in anti-itch formulations that provides temporary relief from itching caused by insect bites, minor skin irritations, poison ivy, sunburn and more.
Pramoxine is used to temporarily relieve itching and pain caused by minor skin irritation such as minor burns/cuts/scrapes, sunburn, eczema, insect bites, cold sores, or rashes from poison ivy, poison oak, or poison sumac. Some products containing pramoxine are also used to temporarily relieve the itching and discomfort from hemorrhoids and certain other problems of the genital/anal area (such as anal fissures, itching around the vagina/rectum).
Indications
Pramoxine hydrochloride (Itch-X, PrameGel, Prax, Tronothane, AmLactin AP) is a local anesthetic that is structurally similar to dyclonine and unrelated to the esteror amide-type compounds.Apply to affected area t.i.d. to q.i.d., as directed by a physician. Useful for patients sensitive to ester and/or amide anesthetics. Onset of anesthesia is within minutes. Duration of anesthesia is 2 to 4 hours.
Clinical Use
Pramoxine is an amino-ether which, like dyclonine, is used as a topical agent in the form of its hydrochloride. Pramoxine hydrochloride may be used for anaesthesia of minor skin wounds and the relief of haemomhoids and other anorectal disorders.The drug is an ingredient of many proprietary topical products, and the U.S.P. has official cream and gel formulations.
Tips: HCl soluble in water, base insoluble in water. (Some Base dissolves in hot water!)
Local anesthesia strength: The anesthesia effect of some base is stronger than HCl.
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Frequently Asked Questions (FAQ)
What is Pramoxine and how does it differ from other local anesthetics?
Pramoxine (also known as pramocaine) has a unique chemical structure containing ether functional groups and a morpholine radical, rather than the ester or amide groups typically found in other local anesthetics. This structure helps reduce toxicity while maintaining effective local anesthetic action.
What conditions is Pramoxine Hydrochloride used to treat?
It is widely used in anti-itch formulations to provide temporary relief from pain and itching caused by insect bites, minor burns, cuts, scrapes, sunburn, eczema, poison ivy, and minor skin irritations. It is also used to relieve discomfort from hemorrhoids and other anorectal issues.
How fast does Pramoxine work and how long does it last?
The onset of anesthesia with Pramoxine hydrochloride occurs within minutes of application. The duration of the anesthetic effect typically lasts between 2 to 4 hours.
Is Pramoxine suitable for patients sensitive to common anesthetics?
Yes. Because Pramoxine is structurally unrelated to ester-type or amide-type anesthetic compounds, it is a highly useful alternative for patients who have known sensitivities or allergies to those classes of local anesthetics.
What is the difference in solubility between Pramoxine HCl and Pramoxine Base?
Pramoxine Hydrochloride (HCl) is soluble in water, whereas Pramoxine Base is generally insoluble in water, though some base forms can dissolve in hot water. Additionally, the anesthetic effect of the base form is typically stronger than that of the HCl form.