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Pramoxine Hydrochloride Powder CAS: 637-58-1 - Local Anesthetic Supplier and Factory in China
Description
Pramoxine, also known as pramocaine, is different from other local anesthetic compounds in chemical structure. Active groups which are carboxylic acid derivatives like ester and amide are not present in this molecule. The drug molecule consists of ether functional groups that are much less active on a chemical level. The presence of the free radical morpholine in this compound is the cause of the reduction of the factor of toxicity and pharmacological activity. In pramoxine, toxicity is reduced but the local anesthetic affect is maintained.
Uses
Pramoxine Hydrochloride is used as a local anaesthetic and often in anti-itch formulations that provides temporary relief from itching caused by insect bites, minor skin irritations, poison ivy, sunburn and more.
Pramoxine is used to temporarily relieve itching and pain caused by minor skin irritation such as minor burns/cuts/scrapes, sunburn, eczema, insect bites, cold sores, or rashes from poison ivy, poison oak, or poison sumac. Some products containing pramoxine are also used to temporarily relieve the itching and discomfort from hemorrhoids and certain other problems of the genital/anal area (such as anal fissures, itching around the vagina/rectum).
Indications
Pramoxine hydrochloride (Itch-X, PrameGel, Prax, Tronothane, AmLactin AP) is a local anesthetic that is structurally similar to dyclonine and unrelated to the ester or amide-type compounds. Apply to affected area t.i.d. to q.i.d., as directed by a physician. Useful for patients sensitive to ester and/or amide anesthetics. Onset of anesthesia is within minutes. Duration of anesthesia is 2 to 4 hours.
Onset: Within Minutes
Duration: 2 to 4 Hours
Clinical Use: Pramoxine is an amino-ether which, like dyclonine, is used as a topical agent in the form of its hydrochloride. Pramoxine hydrochloride may be used for anaesthesia of minor skin wounds and the relief of haemorrhoids and other anorectal disorders. The drug is an ingredient of many proprietary topical products, and the U.S.P. has official cream and gel formulations.
Solubility Tip: HCl is soluble in water, whereas the base form is insoluble in water (although some base dissolves in hot water).
Local Anesthesia Strength: The anesthetic effect of some base forms is stronger than their HCl counterparts.
Anesthetic Strength Ranking:
Tetracaine > Lidocaine > Benzocaine > Procaine
Details
Frequently Asked Questions
Q What makes the chemical structure of Pramoxine unique compared to other local anesthetics?
Unlike traditional local anesthetics, Pramoxine does not contain ester or amide active groups. Instead, it features ether functional groups and a morpholine free radical, which significantly reduces its toxicity while fully maintaining its local anesthetic efficacy.
Q What conditions can Pramoxine Hydrochloride temporarily relieve?
It is widely used to temporarily relieve pain and itching associated with minor skin irritations, insect bites, minor burns, cuts, scrapes, sunburn, eczema, cold sores, and rashes caused by poison ivy, poison oak, or poison sumac. It is also used for discomfort from hemorrhoids and other anorectal conditions.
Q How often should Pramoxine Hydrochloride be applied?
It is generally recommended to apply Pramoxine Hydrochloride to the affected area three to four times daily (t.i.d. to q.i.d.), or strictly as directed by a physician.
Q How fast does Pramoxine work, and how long does the effect last?
The onset of local anesthesia begins within minutes after application, and the relief typically lasts for a duration of 2 to 4 hours.
Q Is Pramoxine safe for individuals allergic to other anesthetics?
Yes, because Pramoxine is structurally unrelated to ester or amide-type compounds, it is a highly useful alternative for patients who are sensitive or allergic to traditional ester and/or amide local anesthetics.
Q What is the solubility difference between Pramoxine HCl and Pramoxine Base?
Pramoxine Hydrochloride (HCl) is soluble in water, whereas Pramoxine Base is insoluble in water (although some base can dissolve in hot water). Additionally, the anesthetic strength of the base form is generally stronger than the HCl form.