Local Anesthesia
Local Anesthetic Drug Tetracaine Base Powder CAS 94-24-6
What is Tetracaine ?
Tetracaine is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount .
Function
99.9% Pure Tetracaine powder cas 94-24-6 is a benzoate ester with anesthetic properties. Upon administration, 99.9% Pure Tetracaine powder cas 94-24-6 reversibly binds voltage-gated sodium ion channels in neuronal cell membranes and inhibits sodium influx. This prevents the initiation and conduction of nerve impulses, and stabilizes neuronal membranes. This results in a loss of sensation, and thereby provides analgesia and anesthesia.
Application
Tetracaine, also known as amethocaine, is an esterlocal anesthetic used to numb the eyes, nose, or throat.It may also be applied to the skin before starting anintravenous to decrease pain from the procedure.Typically it is applied as a liquid to the area. Onset ofeffects when used in the eyes.
Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
Tips: hcl soluble in water, base insoluble in water. (Some Base dissolves in hot water!)
Local anesthesia strength: the anesthesia effect of some base is stronger than hcl)
Tetracaine>Lidocaine>Benzocaine>Procaine
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