Local Anesthetic Drug Bupivacaine hydrochloride Powder CAS 14252-80-3

Bupivacaine is an amide-type, long-acting local anesthetic. Bupivicaine reversibly binds to specific Sodium ion channels in the neuronal membrane, resulting in a decrease in the voltage-dependent membrane permeability to Sodium ions and membrane stabilization; inhibition of depolarization and nerve impulse conduction; and a reversible loss of sensation.

The amide local anesthetics including lidocaine, bupivacaine and Ropivacaine are commonly used for pain control during minor surgery or invasive procedures such as biopsies, small excisions or dental work. These local anesthetics have not been linked to serum enzyme elevations, but when given as constant infusions or repeated injections have been occasionally mentioned as possible causes of clinically apparent liver injury.

1. Painless delivery cesarean section operation

2. Cervical brachial plexus block anesthesia operation

3. Intermuscular sulcus brachial plexus nerve block operation

4. Epidural analgesia after prostate surgery

5. Obstetric surgery

6, lumbar anesthesia surgery

7. Breast surgery

8. Lumbar anesthesia for anorectal surgery

9. Spinal anesthesia for tibia surgery

10. Kidney transplantation 

Ropivacaine hydrochloride monohydrate has been used as an analyte in tandem mass spectrometry and as an amide-based local anaesthetic to test its effect on breast cancer cell methylation.

It is used for local anesthesia and postoperative analgesia

Uses    antineoplastic

Uses    Sodium channel blocker, local anesthetic

Uses    Bupivacaine Hydrochloride is the salt form of Bupivacaine (B689561);  is a sodium channel blocker, local anesthetic.

Tips: hcl soluble in water, base insoluble in water. (Some Base dissolves in hot water!)

Local anesthesia strength: the anesthesia effect of some base is stronger than hcl)

Tetracaine>Lidocaine>Benzocaine>Procaine