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Lidocaine Hydrochloride Powder CAS 73-78-9 from China Suppliers and Factory - Local Anesthetic Drug
What is lidocaine?
Lidocaine acts as a local anesthetic by reversibly blocking sodium channels and blocking the transmission of action potentials along nerve fibers. Sensory fibers are blocked earlier than motor fibers, so low doses of lidocaine can act as a selective sensory block. Lidocaine also has antiarrhythmic effects, belonging to class I and b antiarrhythmic drugs.
Function
Lidocaine is suitable for acute ventricular arrhythmias, including premature ventricular beats, ventricular tachycardia, and ventricular fibrillation, caused by acute myocardial infarction, surgery, digitalism, and cardiac catheterization. Secondly, it is also used for epileptic status.
Application
Lidocaine is the first-line agent for the treatment of ventricular arrhythmias caused by acute and severe hemodynamic abnormalities. It is also effective for some supraventricular arrhythmias, such as bypass mediated supraventricular tachycardia, and acute episodes or parasympathetic mediated cardioversion of atrial fibrillation. It is widely used for surface anesthesia of mucous membranes (e.g. before endotracheal intubation).
EMLA cream is used to anesthetize the skin surface before intravenous catheterization. To ensure the anesthetic effect, apply it to the skin for 45 to 60 minutes, and wrap it with an airtight dressing to promote absorption. EMLA is very useful for ear vein catheterization in rabbits and for intravenous catheterization in young dogs and cats.
Tips
HCL is soluble in water, while base is insoluble in water (some base dissolves in hot water).
Local Anesthesia Strength (The anesthesia effect of some base is stronger than HCL):
Tetracaine > Lidocaine > Benzocaine > Procaine
Details
Frequently Asked Questions
Q:
How does lidocaine function as a local anesthetic?
Lidocaine acts as a local anesthetic by reversibly blocking sodium channels, which blocks the transmission of action potentials along nerve fibers.
Q:
What cardiac conditions is lidocaine suitable for?
Lidocaine is suitable for acute ventricular arrhythmias, including premature ventricular beats, ventricular tachycardia, and ventricular fibrillation caused by acute myocardial infarction, surgery, digitalism, and cardiac catheterization.
Q:
How should EMLA cream be applied for effective skin anesthesia?
To ensure the anesthetic effect, EMLA cream should be applied to the skin for 45 to 60 minutes and wrapped with an airtight dressing to promote absorption before intravenous catheterization.
Q:
What is the difference in water solubility between lidocaine HCL and base?
Lidocaine HCL is soluble in water, whereas lidocaine base is insoluble in cold water, though some base can dissolve in hot water.
Q:
How does lidocaine compare to other local anesthetics in terms of strength?
The relative local anesthesia strength is ordered as follows: Tetracaine > Lidocaine > Benzocaine > Procaine. Additionally, the anesthesia effect of some base forms is stronger than HCL.