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High Purity Tianeptine Sodium Salt CAS 30123-17-2 from Reliable China Suppliers and Factory - Safe Delivery
Description
1. Tianeptine sodium salt is a salt of Tianeptine. Tianeptine is an atypical antidepressant. It is an agonist of the μ-opioid receptor (MOR; EC50s = 194 and 641 nM for human and mouse receptors, respectively, in a BRET assay for G protein activation) and also has effects on the glutamate system. Tianeptine (30 mg/kg) decreases immobility in the forced swim test in wild-type, but not MOR knockout mice, indicating antidepressant-like activity dependent on MORs. It increases locomotor activity at a dose of 30, but not 10 mg/kg, in the open field test and increases paw withdrawal latency in the hot-plate test in mice. Tianeptine modulates AMPA receptor activity by increasing phosphorylation of the AMPA receptor GluR1 subunit in the frontal cortex and hippocampal CA3 region in mice. It prevents increases in glial glutamate transporter 1 (GLT-1) expression induced by chronic restraint stress in the hippocampal CA3 region in rats when administered at a dose of 10 mg/kg per day for 21 days. It also reverses increases in extracellular glutamate levels induced by acute restraint stress in the basolateral nucleus of the amygdala in rats.
2. Tianeptine sodium salt is a structurally novel, serotonin specific antidepressant. It is useful in the treatment of neurotic and reactive depressions, as well as depressive states accompanied by anxiety. Tianeptine (sodium salt) is an analytical reference standard categorized as an opioid. Tianeptine has been abused and associated with overdose and death. Formulations containing tianeptine have been used in the treatment of depression. This product is intended for use in analytical forensic applications. This product is also available as a general research tool.
Application
Tianeptine sodium salt is a tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Tianeptine sodium salt hydrate has been used as a selective serotonin reuptake enhancer (SSRE) positive control during serotonin transporter (SERT) assay in human embryonic kidney 293 cell lines. Tianeptine (INN) (Stablon, Coaxil, Tatinol) is a SSRE drug used for treating major depressive episodes (mild, moderate, or severe). Tianeptine commonly used for depression. It is also used for pain, asthma, anxiety, and many other conditions, but there is no good scientific evidence to support these other uses.
Uses & Effects
Tianeptine Sodium, also known as stablon, is a drug primarily used in the treatment of Major depressive disorder. It has also been used to treat irritable bowel syndrome and asthma. Tianeptine has antidepressant and anti-anxiety properties.
Tianeptine Sodium has a variety of effects on the body, including motivation enhancement, anxiety suppression, cognitive euphoria, focus enhancement, rejuvenation, and cognitive fatigue.
Tianeptine is antidepressant. The animal has the hippocampus pyramidal cells increased spontaneous activity, and accelerating its function was inhibited after recovery; increase in cortical and hippocampal neurons at sites of 5-serotonin reuptake.
Tianeptine is without the following adverse effects:
- Sleep and alertness disruptions
- Cardiovascular system complications
- Cholinergic system issues (without anticholinergic symptoms)
- Drug craving
Details
Frequently Asked Questions
What is Tianeptine Sodium Salt?
Tianeptine sodium salt is a salt of Tianeptine, which functions as an atypical, structurally novel, and serotonin-specific antidepressant. It is primarily used in scientific research, analytical forensics, and the treatment of depressive disorders.
How does Tianeptine Sodium Salt work physiologically?
It acts as an agonist of the μ-opioid receptor (MOR) and modulates the glutamate system. It increases the phosphorylation of the AMPA receptor GluR1 subunit, prevents stress-induced increases in glial glutamate transporter 1 (GLT-1) expression, and regulates extracellular glutamate levels.
What are the primary applications and uses of Tianeptine Sodium?
It is mainly used to treat Major Depressive Disorder (mild, moderate, or severe), neurotic and reactive depressions, and depressive states associated with anxiety. It has also been studied for irritable bowel syndrome (IBS) and asthma.
What physiological and cognitive effects does Tianeptine Sodium produce?
It offers motivation enhancement, anxiety suppression, cognitive euphoria, focus enhancement, rejuvenation, and reduces cognitive fatigue.
Does Tianeptine Sodium cause typical antidepressant adverse effects?
No, Tianeptine is notable for not causing typical adverse side effects related to sleep and alertness, the cardiovascular system, the cholinergic system (no anticholinergic symptoms), or drug craving.
Are there safety warnings associated with Tianeptine Sodium Salt?
Yes, tianeptine has been associated with potential abuse, overdose, and serious health risks. It is categorized as an analytical reference standard and is intended for professional laboratory, forensic, and research applications.