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Phenibut, also known as fenibut, phenigamma, and beta-phenyl-gamma-aminobutyric acid, is a derivative of the neurotransmitter GABA. It was developed in Russia, and there it has been used clinically since the 1960s to treat anxiety and related conditions, including insomnia (Lapin, 2001). Phenibut has anxiolytic properties and is commonly compared to benzodiazepines and baclofen. Structurally, phenibut is similar to GABA, with the addition of the phenyl ring. This allows the compound to more easily cross the blood-brain barrier, but also changes its activity profile (Shulgina, 1986). Scientific studies demonstrate that phenibut can be safely used to treat anxiety, depression, epilepsy, speech disorders, and insomnia.

Phenibut is a chemical similar to a brain chemical called gamma-aminobutyric acid (GABA).

Phenibut might decrease anxiety and have other effects on the body, but most research on phenibut has been published in Russia.

Phenibut is an anxiolytic and nootropic drug, discovered in the Soviet Union used to treat several psychiatric disorders. It can be used in the treatment of anxiety, depression, asthenia, post-traumatic stress disorder, stuttering, and vestibular disorders.

When taken by mouth: Phenibut is likely unsafe. Phenibut can cause many side effects, including reduced consciousness, dizziness, nausea, poor balance, and fatigue. Taking large doses can cause trouble breathing, unconsciousness, and death.

Phenibut can cause dependence. People who use phenibut for 3 days or more and then stop taking it might experience withdrawal symptoms. These symptoms can include decreased appetite, nausea, muscle aches, fast heart rate, anxiety, agitation, trouble sleeping, and seizures.