Hot Products
China Bupivacaine Hydrochloride Powder Suppliers - Local Anesthetic CAS 14252-80-3 from Factory
Tetracaine Specification
Bupivacaine is an amide-type, long-acting local anesthetic. Bupivicaine reversibly binds to specific Sodium ion channels in the neuronal membrane, resulting in a decrease in the voltage-dependent membrane permeability to Sodium ions and membrane stabilization; inhibition of depolarization and nerve impulse conduction; and a reversible loss of sensation.
The amide local anesthetics including lidocaine, bupivacaine and Ropivacaine are commonly used for pain control during minor surgery or invasive procedures such as biopsies, small excisions or dental work. These local anesthetics have not been linked to serum enzyme elevations, but when given as constant infusions or repeated injections have been occasionally mentioned as possible causes of clinically apparent liver injury.
Application
- 1. Painless delivery cesarean section operation
- 2. Cervical brachial plexus block anesthesia operation
- 3. Intermuscular sulcus brachial plexus nerve block operation
- 4. Epidural analgesia after prostate surgery
- 5. Obstetric surgery
- 6, lumbar anesthesia surgery
- 7. Breast surgery
- 8. Lumbar anesthesia for anorectal surgery
- 9. Spinal anesthesia for tibia surgery
- 10. Kidney transplantation
Ropivacaine hydrochloride monohydrate has been used as an analyte in tandem mass spectrometry and as an amide-based local anaesthetic to test its effect on breast cancer cell methylation.
It is used for local anesthesia and postoperative analgesia
Uses antineoplastic
Uses Sodium channel blocker, local anesthetic
Uses Bupivacaine Hydrochloride is the salt form of Bupivacaine (B689561); is a sodium channel blocker, local anesthetic.
Solubility Tips
hcl soluble in water, base insoluble in water. (Some Base dissolves in hot water!)
Local Anesthesia Strength
the anesthesia effect of some base is stronger than hcl)
Tetracaine > Lidocaine > Benzocaine > Procaine
details
Frequently Asked Questions
Q1
What is Bupivacaine and how does it function?
Bupivacaine is an amide-type, long-acting local anesthetic. It works by reversibly binding to specific Sodium ion channels in the neuronal membrane, which decreases the voltage-dependent membrane permeability to Sodium ions, stabilizes the membrane, inhibits depolarization and nerve impulse conduction, and results in a reversible loss of sensation.
Q2
What are the primary clinical applications of local anesthetics like Bupivacaine?
They are widely used for pain control during minor surgeries and invasive procedures. Specific applications include painless delivery cesarean sections, cervical and intermuscular sulcus brachial plexus nerve blocks, epidural analgesia after prostate surgery, obstetric surgery, lumbar anesthesia (for anorectal and other surgeries), breast surgery, spinal anesthesia for tibia surgery, and kidney transplantation.
Q3
How does the solubility of local anesthetic HCL compare to its base form?
Local anesthetic HCL forms are generally soluble in water, whereas the base forms are insoluble in water (although some base forms can dissolve in hot water).
Q4
What is the order of local anesthesia strength among common anesthetics?
The relative local anesthesia strength is ordered as follows: Tetracaine > Lidocaine > Benzocaine > Procaine. Additionally, the anesthesia effect of some base forms is stronger than their HCL counterparts.
Q5
Are amide local anesthetics safe for the liver?
Amide local anesthetics (including lidocaine, bupivacaine, and ropivacaine) are typically not linked to elevations in serum enzymes. However, when administered via constant infusions or repeated injections, they have occasionally been reported as possible causes of clinically apparent liver injury.
Q6
What are the research applications of Ropivacaine hydrochloride monohydrate?
Ropivacaine hydrochloride monohydrate is utilized as an analyte in tandem mass spectrometry and as an amide-based local anesthetic to study and test its developmental effects on breast cancer cell methylation.