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Bupivacaine Hydrochloride Powder CAS 14252-80-3 - China Suppliers & Factory for Local Anesthetic Applications
Tetracaine Specification
Bupivacaine is an amide-type, long-acting local anesthetic. Bupivicaine reversibly binds to specific Sodium ion channels in the neuronal membrane, resulting in a decrease in the voltage-dependent membrane permeability to Sodium ions and membrane stabilization; inhibition of depolarization and nerve impulse conduction; and a reversible loss of sensation.
The amide local anesthetics including lidocaine, bupivacaine and Ropivacaine are commonly used for pain control during minor surgery or invasive procedures such as biopsies, small excisions or dental work. These local anesthetics have not been linked to serum enzyme elevations, but when given as constant infusions or repeated injections have been occasionally mentioned as possible causes of clinically apparent liver injury.
Application
- 01. Painless delivery cesarean section operation
- 02. Cervical brachial plexus block anesthesia operation
- 03. Intermuscular sulcus brachial plexus nerve block operation
- 04. Epidural analgesia after prostate surgery
- 05. Obstetric surgery
- 06. Lumbar anesthesia surgery
- 07. Breast surgery
- 08. Lumbar anesthesia for anorectal surgery
- 09. Spinal anesthesia for tibia surgery
- 10. Kidney transplantation
Ropivacaine hydrochloride monohydrate has been used as an analyte in tandem mass spectrometry and as an amide-based local anaesthetic to test its effect on breast cancer cell methylation.
It is used for local anesthesia and postoperative analgesia.
Key Uses & Properties
Antineoplastic: Evaluated for its effects on cancer cell methylation.
Sodium Channel Blocker: Bupivacaine Hydrochloride serves as a potent sodium channel blocker and local anesthetic.
Solubility Tip: HCl forms are soluble in water, whereas base forms are insoluble in water (Note: Some base forms can dissolve in hot water).
Local Anesthesia Strength (Anesthetic effect of base forms is generally stronger than HCl):
Tetracaine
Lidocaine
Benzocaine
Procaine
Details
Frequently Asked Questions
Q What is Bupivacaine and how does it function?
Bupivacaine is a long-acting local anesthetic of the amide type. It works by reversibly binding to specific sodium ion channels in the neuronal membrane, reducing sodium permeability, stabilizing the membrane, and preventing nerve impulse conduction to block pain sensation.
Q What are the primary clinical applications of Bupivacaine?
It is widely used for surgical anesthesia and postoperative pain relief, including painless delivery, cesarean sections, brachial plexus blocks, epidural analgesia after prostate surgery, obstetric operations, spinal anesthesia, and kidney transplantations.
Q What is the difference between local anesthetic HCl and free base forms?
The Hydrochloride (HCl) forms of local anesthetics are soluble in water, whereas the free base forms are generally insoluble in water (though some base forms may dissolve in hot water). Additionally, free base forms typically provide a stronger local anesthetic effect than their HCl counterparts.
Q How does the anesthetic strength compare among common local anesthetics?
Based on local anesthesia strength, the potency ranks in descending order as follows: Tetracaine > Lidocaine > Benzocaine > Procaine.
Q Can amide-type local anesthetics cause liver injury?
Amide local anesthetics like lidocaine, bupivacaine, and ropivacaine are not typically linked to serum enzyme elevations. However, when administered via constant infusions or repeated injections, they have occasionally been reported as potential causes of clinically apparent liver injury.