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Bupivacaine Hydrochloride Powder CAS 14252-80-3 - China Suppliers and Factory for Local Anesthetic Drug
Tetracaine Specification
Bupivacaine is an amide-type, long-acting local anesthetic. Bupivicaine reversibly binds to specific Sodium ion channels in the neuronal membrane, resulting in a decrease in the voltage-dependent membrane permeability to Sodium ions and membrane stabilization; inhibition of depolarization and nerve impulse conduction; and a reversible loss of sensation.
The amide local anesthetics including lidocaine, bupivacaine and Ropivacaine are commonly used for pain control during minor surgery or invasive procedures such as biopsies, small excisions or dental work. These local anesthetics have not been linked to serum enzyme elevations, but when given as constant infusions or repeated injections have been occasionally mentioned as possible causes of clinically apparent liver injury.
Application
1. Painless delivery cesarean section operation
2. Cervical brachial plexus block anesthesia operation
3. Intermuscular sulcus brachial plexus nerve block operation
4. Epidural analgesia after prostate surgery
5. Obstetric surgery
6. Lumbar anesthesia surgery
7. Breast surgery
8. Lumbar anesthesia for anorectal surgery
9. Spinal anesthesia for tibia surgery
10. Kidney transplantation
Ropivacaine hydrochloride monohydrate has been used as an analyte in tandem mass spectrometry and as an amide-based local anaesthetic to test its effect on breast cancer cell methylation.
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It is used for local anesthesia and postoperative analgesia
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Uses: antineoplastic
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Uses: Sodium channel blocker, local anesthetic
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Uses: Bupivacaine Hydrochloride is the salt form of Bupivacaine (B689561); is a sodium channel blocker, local anesthetic.
Solubility Tips
hcl soluble in water, base insoluble in water. (Some Base dissolves in hot water!)
Local Anesthesia Strength
The anesthesia effect of some base is stronger than hcl.
Tetracaine
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Lidocaine
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Benzocaine
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Procaine
Details
Frequently Asked Questions
What is Bupivacaine and how does it work?
Bupivacaine is an amide-type, long-acting local anesthetic. It works by reversibly binding to specific Sodium ion channels in the neuronal membrane, which decreases the voltage-dependent membrane permeability to Sodium ions, stabilizes the membrane, inhibits depolarization and nerve impulse conduction, and results in a reversible loss of sensation.
What are the common surgical applications for these local anesthetics?
They are widely used in various procedures, including painless delivery cesarean sections, cervical brachial plexus block anesthesia, intermuscular sulcus brachial plexus nerve blocks, epidural analgesia after prostate surgery, obstetric surgery, lumbar anesthesia, breast surgery, anorectal surgery, spinal anesthesia for tibia surgery, and kidney transplantation.
How do Ropivacaine and Bupivacaine Hydrochloride differ in their applications?
Ropivacaine hydrochloride monohydrate is used as an analyte in tandem mass spectrometry and to test its effect on breast cancer cell methylation. Bupivacaine Hydrochloride is the salt form of Bupivacaine, acting as a sodium channel blocker and local anesthetic primarily for local anesthesia and postoperative analgesia.
What are the solubility differences between the HCL and Base forms?
Generally, the HCL forms of these anesthetics are soluble in water, whereas the Base forms are insoluble in water. However, some Base forms can dissolve in hot water.
How does the local anesthesia strength compare among different agents?
The local anesthesia strength follows the order of Tetracaine > Lidocaine > Benzocaine > Procaine. Additionally, the anesthetic effect of some base forms is stronger than their HCL counterparts.